Anti-NPC1 Rabbit Polyclonal Antibody

Proveedor: Bioss
BS-6764R
BOSSBS-6764REA 725 EUR
BOSSBS-6764R
Anti-NPC1 Rabbit Polyclonal Antibody
Anticuerpos
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomalMore Product Information
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