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Numero del catalogo: (PRSI92-153)

Proveedor: ProSci Inc.

Descripción: Caspase 14 (CASP14) is an enzyme that belongs to the peptidase C14A family. The Caspase 14 protein is complexed of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes, which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerise to form the active enzyme. CASP14 has been shown to be processed and activated by Caspase 8 and Caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. It is believed to be a non-apoptotic caspase which is involved in epidermal differentiation, keratinocyte differentiation and cornification. CASP14 probably regulates maturation of the epidermis by proteolytically processing filaggrin.

UOM: 1 * 50 µG

Promoción

Proveedor: Thermo Fisher Scientific

Descripción: Collagenase contains a mixture of collagenase, clostripain, trypsin, caseinase and other lytic enzymes.

Numero del catalogo: (PRSI92-149)

Proveedor: ProSci Inc.

Descripción: Carbonic Anhydrase 14 (CA14) belongs to the Alpha-Carbonic Anhydrase family. It is highly expressed in all parts of the central nervous system and lowly expressed in adult liver, heart, small intestine, colon, kidney, urinary bladder, and skeletal muscle. CA14 along with other Carbonic Anhydrases (CAs) participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA14 is predicted to be a type I membrane protein and catalyses the reversible hydration of carbon dioxide.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI92-325)

Proveedor: ProSci Inc.

Descripción: Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a 78-kDa, calcium dependent enzyme,It belongs to the transglutaminase superfamily and transglutaminase family. The protein encoded by this TGM2 gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. TGM2 is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI91-281)

Proveedor: ProSci Inc.

Descripción: Arylsulfatase A (ARSA) is a lysosomal enzyme that breaks down Cerebroside 3-Sulfate, a major constituent of the myelin sheet, into Cerebroside and Sulfate. The ARSA deficiency results in Metachromatic Leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms. Recombinant Human ARSA corresponds to the ARSA mature peptide and has sulfatase activity.

UOM: 1 * 50 µG

Promoción

Proveedor: OMEGA BIO-TEK

Descripción: For enzyme digestion during DNA and RNA preparation. Both OB Protease and Proteinase K offer broad substrate specificity with high activity for a wide range of salts, denaturant and detergent, pH, and temperature conditions. Proteinase K is a subtilisin-type protease isolated from the saprophytic fungus <i>Tritirachiumalbum</i> and is particularly suitable for short digestion times. It possesses a high specific activity which remains stable over a wide range of temperatures and pH values with substantially increased activity at higher temperature.

FDS Certificados

Numero del catalogo: (EM0821)

Proveedor: Thermo Fisher Scientific

Descripción: CpG methyltransferase enzyme methylates the C5 position on the base moiety of all cytosine nucleotides contained in unmethylated or hemimethylated double stranded DNA in a 5'-CpG-3' context. Thermo Scientific M.SssI is specifically formulated for fast reaction times without compromising the reaction efficiency. The enzyme completes modification of all CpGs in 15 minutes at 37 °C. In addition, the enzyme has been specifically validated for use with genomic DNA – the primary substrate in epigenetic studies.

UOM: 1 * 1 KIT

Promoción

Numero del catalogo: (PRSI91-456)

Proveedor: ProSci Inc.

Descripción: Tryptases are Trypsin-like Serine Proteases. beta -Tryptases are the main isoenzymes in mast cells. beta tryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, beta -Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, beta -Tryptases are released and participate in provoking inflammatory conditions . beta -Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic disorders.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI92-334)

Proveedor: ProSci Inc.

Descripción: RNASET2, also known as RNASE6PL, is short for bonuclease T2. It is a 256 aa. protein which belongs to the RNase T2 family. RNASET2 is a secreted protein, and is higher expressed in the temporal lobe and fetal brain. This protein can be inhibited by Zn₂⁺ and Cu₂⁺. It has ribonuclease activity, with higher activity at acidic pH and is probably involved in lysosomal degradation of ribosomal RNA. It also plays a role in cellular RNA catabolism.

UOM: 1 * 50 µG

Promoción

Proveedor: G-Biosciences

Descripción: Proteinase K (also protease K, endopeptidase K, peptidase K or Tritirachium alkaline phosphatase) (EC 3.4.21.64) is a non specifc, broad spectrum serine protease that is isolated from the saprophytic fungus <i>Tritirachium album</i>.

Numero del catalogo: (PRSI92-133)

Proveedor: ProSci Inc.

Descripción: Bile Salt Sulfotransferase (SULT2A1( is a cytosolic enzyme that belongs to the Sulfotransferase 1 family. SULT2A1 is primarily expressed in the liver and adrenal tissues, and to a lesser extent in the kidney. SULT2A1 utilises 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor, and it catalyse the sulfonation of steroids and bile acids in the liver and adrenal glands. SULT2A1 may have a role in the inherited adrenal androgen excess.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI92-137)

Proveedor: ProSci Inc.

Descripción: Sialic Acid Synthase (NANS) is an enzyme that contains one AFP-like domain. NANS is ubiquitous and plays a role in the biosynthetic pathways of sialic acids. NANS produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). It also can use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI91-984)

Proveedor: ProSci Inc.

Descripción: Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pancreas. CDO1 can also be detected in hepatoblastoma HepG2 cells. CDO1 catalyses the conversion of L-cysteine to cysteine sulfinic acid by incorporation of dioxygen. CDO1 is a vital regulator of cellular cysteine concentrations and has an essential role in maintaining the hepatic concentration of intracellular free cysteine within a proper narrow range. CDO1 is able to alter intracellular cysteine levels and glutathione levels.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI92-161)

Proveedor: ProSci Inc.

Descripción: Tryptophan 5-hydroxylase 2 (TPH2) is an isozyme member of the biopterin-dependent aromatic amino acid hydroxylase family. TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression found in the raphe nucleus of the midbrain. TPH2 catalyses the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD). Defects in TPH2 are the cause of psychiatric diseases such as bipolar affective disorder and major depression.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI91-230)

Proveedor: ProSci Inc.

Descripción: Phosphomannomutase 2 (PMM2) is an enzyme that is a member of the highly variable methyltransferase superfamily. PMM2 is a cytoplasmic protein and catalyses the isomerisaion of mannose 6-phosphate to mannose 1-phosphate.In addition, PMM2 involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose that required for a number of critical mannosyl transfer reactions. Defects in PMM2 can results in congenital disorder of glycosylation type 1A (CDG1A). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (69182-3)

Proveedor: Merck Millipore (Novagen)

Descripción: Desoxyribonuclease I

UOM: 1 * 1.000 UE

Promoción