Descripción: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.Tissue specificity; Brain.Involvement in disease; Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.

Numero del catalogo: BOSSBS-6929R-CY5.5

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.Tissue specificity; Brain.Involvement in disease; Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.

Numero del catalogo: BOSSBS-6929R-A350

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: VWR® heavy-duty vortex mixers have an efficient motor enabling units to operate in continuous mode and handle all accessories over the entire speed range. Choice of two modes of operation: 'Touch' mode for mixing tubes when the cup head or universal holder with cover is depressed or 'On' mode when using any of the accessory attachments for continuous operation.

Numero del catalogo: 444-7130

UOM: 1 * 1 UN

Proveedor: VWR Collection

Promoción

Descripción: C5orf20 is a intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans

Numero del catalogo: BOSSBS-15199R-FITC

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: C5orf20 is a intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans

Numero del catalogo: BOSSBS-15199R-A350

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: C5orf20 is a intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans

Numero del catalogo: BOSSBS-15199R-A555

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.Tissue specificity; Brain.Involvement in disease; Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B); also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS). ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.Defects in DCTN1 are the cause of Perry syndrome (PERRYS); also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.

Numero del catalogo: BOSSBS-6929R-A647

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: C5orf20 is a intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans

Numero del catalogo: BOSSBS-15199R-CY5

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: C5orf20 is a intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans

Numero del catalogo: BOSSBS-15199R-CY7

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Trace amines are endogenous molecules structurally related to classical biogenic amines that are linked to psychiatric conditions. A family of G-protein coupled receptors referred to as trace-amine-associated receptors (TAAR) are activated by trace amines and are present in very low levels in mammalian tissue. TaRs contain several structural features that are similar to the rhodopsin ∫-adrenergic receptor superfamily, including the positions of the seven transmembrane regions that provide common ligand-binding pockets as well as the short N- and C-terminal domains. TAAR proteins are potential targets for drugs of abuse, such as amphetamine and MDMA, as well as neuropsychiatric disorders including schizophrenia, depression, and attention deficit disorder.

Numero del catalogo: BOSSBS-12023R-HRP

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Trace amines are endogenous molecules structurally related to classical biogenic amines that are linked to psychiatric conditions. A family of G-protein coupled receptors referred to as trace-amine-associated receptors (TAAR) are activated by trace amines and are present in very low levels in mammalian tissue. TaRs contain several structural features that are similar to the rhodopsin ∫-adrenergic receptor superfamily, including the positions of the seven transmembrane regions that provide common ligand-binding pockets as well as the short N- and C-terminal domains. TAAR proteins are potential targets for drugs of abuse, such as amphetamine and MDMA, as well as neuropsychiatric disorders including schizophrenia, depression, and attention deficit disorder.

Numero del catalogo: BOSSBS-12023R-CY7

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Trace amines are endogenous molecules structurally related to classical biogenic amines that are linked to psychiatric conditions. A family of G-protein coupled receptors referred to as trace-amine-associated receptors (TAAR) are activated by trace amines and are present in very low levels in mammalian tissue. TaRs contain several structural features that are similar to the rhodopsin -adrenergic receptor superfamily, including the positions of the seven transmembrane regions that provide common ligand-binding pockets as well as the short N- and C-terminal domains. TAAR proteins are potential targets for drugs of abuse, such as amphetamine and MDMA, as well as neuropsychiatric disorders including schizophrenia, depression, and attention deficit disorder.

Numero del catalogo: BOSSBS-12023R-A750

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate. One such coactivator is KAT13C / nuclear receptor coactivator 2 (NCOA2), also termed Glucocorticoid receptor-interacting protein 1 (GRIP1).

Numero del catalogo: BOSSBS-3561R-A750

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Sauvagine is a 40-residue peptide isolated and characterised from frog skin. It shares significant structural homology with and elicits similar biological responses as corticotropin-releasing factor (CRF). It has high affinity for both the CRF1 and CRF2 receptors (and low affinity for the CRF binding protein), suggesting its potential as a pharmacological tool for the study of these receptor sub-types. Due to the binding to CRF2 receptors and their role in the release of ACTH and beta-endorphin during stress, possible areas of research with this ligand include anxiety, depression and obesity.

Numero del catalogo: BOSSBS-11424R-A750

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Sauvagine is a 40-residue peptide isolated and characterised from frog skin. It shares significant structural homology with and elicits similar biological responses as corticotropin-releasing factor (CRF). It has high affinity for both the CRF1 and CRF2 receptors (and low affinity for the CRF binding protein), suggesting its potential as a pharmacological tool for the study of these receptor sub-types. Due to the binding to CRF2 receptors and their role in the release of ACTH and beta-endorphin during stress, possible areas of research with this ligand include anxiety, depression and obesity.

Numero del catalogo: BOSSBS-11424R-A680

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate. One such coactivator is KAT13C / nuclear receptor coactivator 2 (NCOA2), also termed Glucocorticoid receptor-interacting protein 1 (GRIP1).

Numero del catalogo: BOSSBS-3561R-CY5.5

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción