Esta buscando: Hexyl+nicotinate

Numero del catalogo: (PRSI90-355)

Proveedor: ProSci Inc.

Descripción: Nuclear NMNAT isoform. Catalyses the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Interacts with PARP-1/ARTD1. Protects against axonal degeneration following mechanical or toxic insults. Widely expressed.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI90-354)

Proveedor: ProSci Inc.

Descripción: Nuclear NMNAT isoform. Catalyses the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Interacts with PARP-1/ARTD1. Protects against axonal degeneration following mechanical or toxic insults. Widely expressed.

UOM: 1 * 10 µG

Promoción

Proveedor: Agilent

Descripción: Each method validation kits contain three HPLC columns with the same column type (i.e., bonded phase, particle size, configuration) but from different manufacturing lots.

Proveedor: Honeywell Chemicals

Descripción: Hexano (mezcla de isómeros) ≥85% (isomers basis, GC), Puriss.

Proveedor: ENZO LIFE SCIENCES

Descripción: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface, and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites, increasing the predicted MW from 200kDa to ~600kDa. The diagram shown indicates the domain structure and functional regions of agrin, as well as domains required for AChR aggregation and alpha-dystroglycan and heparin binding.  Various agrin isoforms are generated by alternative splicing at the X, Y and Z sites, and differ in the presence or absence of small inserts. The isoforms can determine the biological activity of agrin and their expression in specific tissues and stages of development. While no difference in functional activity has been detected between splicing variants at site X, insertion of a 4 aa peptide at site Y modestly increases agrins nAChR clustering activity. Insertion of an 8 aa peptide at splicing site Z increases the clustering activity of soluble rat agrin 10,000 fold.

Numero del catalogo: (PRSI56-130)

Proveedor: ProSci Inc.

Descripción: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

UOM: 1 * 400 µl

New Product Promoción

Numero del catalogo: (PRSI29-828)

Proveedor: ProSci Inc.

Descripción: RAPSN belongs to a family of proteins that are receptor associated proteins of the synapse. It contains a conserved cAMP-dependent protein kinase phosphorylation site. It is believed to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin.This protein belongs to a family of proteins that are receptor associated proteins of the synapse. It contains a conserved cAMP-dependent protein kinase phosphorylation site. It is believed to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Two splice variants have been identified for this gene.

UOM: 1 * 50 µG

Promoción

Proveedor: Honeywell Chemicals

Descripción: Hexano (mezcla de isómeros) ≥95%, Laboratory Reagent

FDS

Proveedor: Agilent

Descripción: These InfinityLab Poroshell 120 1,9 µm columns provide high performance under the highest pressures.

Numero del catalogo: (34493-2.5L)

Proveedor: Honeywell Chemicals

Descripción: Hexano (mezcla de isómeros), CHROMASOLV™ para análisis de residuos de pesticidas, Riedel-de Haën™

UOM: 1 * 2,5 L

FDS Promoción

Proveedor: Agilent

Descripción: Eclipse Plus columns are recommended for initial method development from pH 2 to 9 and provide high resolution and excellent peak shape of all types of compounds.

Numero del catalogo: (PRSI31-093)

Proveedor: ProSci Inc.

Descripción: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA7 is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from CHRNA7 and a novel FAM7A gene.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI91-655)

Proveedor: ProSci Inc.

Descripción: Glycerol-3-Phosphate Dehydrogenase [NAD(+)], Cytoplasmic (GPDH-C) belongs to the NAD-Dependent Glycerol-3-Phosphate Dehydrogenase family. GPDH-C plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of Dihydroxyacetone Phosphate (DHAP) and reducing Nicotine Adenine Dinucleotide (NADH) to Glycerol-3-Phosphate (G3P) and NAD+. GPDH-C is inhibited by zinc ions and sulfate. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. GPDH-C is unlike Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH); they have different substrates.

UOM: 1 * 50 µG

Promoción

Proveedor: Agilent

Descripción: Agilent offers methods development kits to streamline the column collection process used for medium and high pressure LC systems.

Proveedor: Thermo Fisher Scientific

Descripción: Estas columnas ofrecen selectividad exclusiva para analitos aromáticos y moderadamente polares. Adecuadas para muestras complejas donde algunos picos se resuelven bien en una fase de fenilo mientras que otros requieren una fase alquilo convencional. Basadas en la Tecnología CET (Core Enhanced Technology) proporcionan separaciones de alta resolución rápidas sin las contrapresiones elevadas requeridas por las partículas inferiores a 2 µm.

Numero del catalogo: (PROOCHE144)

Proveedor: LGC Standards PROMOCHEM

Descripción: Bis(2-etilhexilo) ftlalato

UOM: 1 * 1 g

Promoción