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Product Image-115-1880

Estera de banco de preparación de quimioterapia estéril, BioClean ChemPrep ™

Proveedor: Nitritex
Descripción: La esterilla de preparación de quimioterapia estéril de BioClean es altamente absorbente.

Certificados

Image Unavailable-BOSSBS-0087R-HRP

Anti-CASP3 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numero del catalogo: (BOSSBS-0087R-HRP)
Proveedor: Bioss
Descripción: The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
UOM: 1 * 100 µl
Product Image-512-0714

Centrifuge, Cellspin® III UNI

Numero del catalogo: (512-0714)
Proveedor: THARMAC GmbH
Descripción: The genius among the centrifuges. Automatic rotor detection and speed adjustment on max. 2000 rpm when using cytorotors.
UOM: 1 * 1 UN
Product Image-BRND137615

Imanes de agitación, PTFE, octogonales, con anillo central

Proveedor: Brand
Descripción: These octagonal shaped PTFE magnetic stirrer bars are ideal for vessels with slightly uneven bottoms. The angular surface creates high turbulence even at low speeds.

Image Unavailable-PRSI90-269

Human recombinant CD40 (from HEK293 cells)

Numero del catalogo: (PRSI90-269)
Proveedor: ProSci Inc.
Descripción: CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal centre formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumour cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
UOM: 1 * 50 µG
Product Image-GRANBN-13-100

Accessories for centrifuge, bench, biomedical, LMC-3000

Proveedor: GRANT INSTRUMENTS
Descripción: Centrífuga de sobremesa, BN-13-75 adapter, for 2-5 ml vacutainers (13×75 mm), for rotor R-12-10

Image Unavailable-BOSSBS-2734R-A680

Anti-Bcl6 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Numero del catalogo: (BOSSBS-2734R-A680)
Proveedor: Bioss
Descripción: Transcriptional repressor mainly required for germinal centre (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
UOM: 1 * 100 µl
Product Image-WITG0.754.250

Flasks, round bottom, with two necks

Numero del catalogo: (WITG0.754.250)
Proveedor: witeg Labortechnik
Descripción: Borosilicate glass 3.3 two necks, parallel side neck.
UOM: 1 * 1 UN
Image Unavailable-BOSSBS-3948R-A680

Anti-LKB1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Numero del catalogo: (BOSSBS-3948R-A680)
Proveedor: Bioss
Descripción: Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal centre in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarisation by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A.
UOM: 1 * 100 µl
Image Unavailable-GRANDENTUBE16

Accesorios para densitómetro de sobremesa para medir la turbidez de suspensiones celulares, DEN-1

Proveedor: GRANT INSTRUMENTS
Descripción: Accesorios para densitómetro de sobremesa para medir la turbidez de suspensiones celulares, DEN-1

New Product

Product Image-115-9221

VWR®, Protectores de Bancos

Proveedor: VWR Collection
Descripción: High quality, smooth, absorbent paper that quickly absorbs liquid spills with a thick, laminated polyethylene layer that prevents seeping onto the work surface.

Certificados

Product Image-535-0033

Sistemas de liofilización, FreeZone®

Proveedor: LABCONCO
Descripción: Diseñado para responder a las necesidades de liofilización de investigación y de laboratorios de planta piloto. Hay disponibles colectores que alcanzan los −50 °C con capacidades de 1 a 18 litros. Sistemas en cascada en colectores de capacidades de 2,5, 6 y 12 litros que alcanzan los −84 °C y que son ideales para congelar muestras de secado con temperaturas eutécticas bajas. Los sistemas de liofilización FreeZone® de sobremesa de −105 °C son apropiados para muestras con puntos de temperaturas eutécticas bajas, incluidas las que contienen pequeñas cantidades de metanol o etanol.

Product Image-ECONEXBBMS30.0

Soporte M para cajas Bio-bin

Proveedor: ECONIX LTD
Descripción: Estos soportes de acero inoxidable han sido diseñados para permitir que las cajas Bio-bin® de 2, 5 y 30 litros se inclinen aproximadamente 15 grados para facilitar el llenado de artículos altos y delgados, por ejemplo, pipetas.

Product Image-521-1894

VWR® Mega Star 600/600R, Centrífugas, de sobremesa, ventiladas/refrigeradas

Proveedor: VWR Collection
Descripción: These small bench top centrifuges are ideal for research and clinical applications in pharmaceutical and biotechnical industries, as well as for academic research. They offer good capacity in a compact design with a smart and simple interface.

Product Image-DENE5101001

Surface protection mats

Proveedor: DEUTSCH NEUMANN
Descripción: Translucent bench mats made from silicone rubber (VMQ).

Product Image-SIMPT330AD15

Adapters for universal centrifuges

Proveedor: Simport Scientific
Descripción: These universal centrifuge adapters are made of acetal plastic.

Consulta de precio
El stock para este material es limitada pero puede estar disponible en un almacén cerca de usted. Por favor, asegúrese de que ha iniciado sesión en la web para que el stock disponible se puede mostrar. Si el call sigue apareciendo y usted necesita ayuda, por favor llámenos al 902 222 897 o por email en webshop.es@avantorsciences.com.
El stock para este material es limitada pero puede estar disponible en un almacén cerca de usted. Por favor, asegúrese de que ha iniciado sesión en la web para que el stock disponible se puede mostrar. Si el call sigue apareciendo y usted necesita ayuda, por favor llámenos al 902 222 897 o por email en webshop.es@avantorsciences.com.
Este producto se trata de un artículo regulado sometido a normativa que restringe su venta. Si procede, nos pondremos en contacto con usted para solicitarle la licencia o declaración de uso necesaria para poder proceder al suministro del producto.
Este producto se trata de un artículo regulado sometido a normativa que restringe su venta.
Si procede, nos pondremos en contacto con usted para solicitarle la licencia o declaración de uso necesaria para poder proceder al suministro del producto.
Este producto ha sido bloqueado por su organización. Por favor, pónganse en contacto con su departamento de compras para obtener más información.
El producto original ya no está disponible. Su sustituto se muestra a continuación.
El producto(s) marcados con este símbolo están descatalogados - se venden hasta acabar stock. Pueden encontrar alternativas buscando con el número de catálogo VWR listado arriba. Si necesita más ayuda, por favor llame al Servicio de atención al cliente de VWR al 902.222.897.
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