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Image Unavailable-BOSSBS-11778R-A680

Anti-DORFIN/RNF19 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Descripción: Dorfin is a multi-pass membrane, RING-IBR type, E3 ubiquitin-protein ligase. It is widely expressed with highest levels found in heart and ubiquitous expression throughout the central nervous system. Dorfin functions by accepting ubiquitin in the form of a thioester from UBCH7 and UBC8 and then transferring it to the targeted substrates. Dorfin is responsible for ubiquitylating synphilin-1, CaSR and mutant variants of SOD-1, a protein at fault for familial ALS (amyotrophic lateral sclerosis). Dorfin physically interacts with VCP (Valosin-containing protein) via its C-terminus. Together these two proteins are associated with the formation of ubiquitylated inclusions (UBIs) that characterize many neurodegenerative disorders, such as Parkinson's disease and ALS. This association with UBIs suggests that Dorfin plays an important role in the disease process.
Numero del catalogo: BOSSBS-11778R-A680
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-12877R-CY3

Anti-BOP1 Rabbit Polyclonal Antibody (Cy3®)

Descripción: Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis.
Numero del catalogo: BOSSBS-12877R-CY3
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-12877R-A350

Anti-BOP1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Descripción: Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis, as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may lead to colorectal tumorigenesis.
Numero del catalogo: BOSSBS-12877R-A350
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-0829R-CY7

Anti-NANOG Rabbit Polyclonal Antibody (Cy7®)

Descripción: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.
Numero del catalogo: BOSSBS-0829R-CY7
UOM: 1 * 100 µl
Proveedor: Bioss
Product Image-HAMI202192

Syringes for HPLC autosamplers, for Spectra-Physics

Descripción: These gas tight syringes are designed for HPLC autosamplers.
Numero del catalogo: HAMI202192
UOM: 1 * 1 UN
Proveedor: HAMILTON BONADUZ
Product Image-DIDAPOD010095

Accessories for optical bench components

Descripción: Material educativo, Accessories, Aplicación: Física , Lens holder, Ø 80 mm
Numero del catalogo: DIDAPOD010095
UOM: 1 * 1 UN
Proveedor: DIDALAB
Product Image-466-0603

VWR® VENTI-Line® Prime, Hornos de secado con convección forzada

Descripción: Los hornos de secado VENTI-Line® están diseñados para todas las tareas de secado y calentamiento convencionales y la esterilización del material de vidrio. Tienen un rango de temperatura que va de 50 a 300 °C y está destinado al uso en laboratorios biológicos, químicos, médicos, farmacéuticos y físicos.
Numero del catalogo: 466-0603
UOM: 1 * 1 UN
Proveedor: VWR Collection
Image Unavailable-BOSSBS-7740R-A488

Anti-CFAP53 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Descripción: CCDC11 is a 514 amino acid protein encode by a gene that maps to human chromosome 18q21.1. Encoding over 300 genes, chromosome 18 contains about 76 million bases. Trisomy 18, or Edwards syndrome, is the second most common trisomy after Downs syndrome. Symptoms of Edwards syndrome include low birth weight, a variety of physical development defects, heart deformations and breathing difficulty. Translocation between chromosome 18 and 14 is the most common translocation in cancers, and occurs in follicular lymphomas. Niemann-Pick disease, hereditary hemorrhagic telangiectasia and erythropoietic protoporphyria are associated with chromosome 18. The TGF∫ modulators, Smad2, Smad4 and Smad7 are encoded by chromosome 18.
Numero del catalogo: BOSSBS-7740R-A488
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-5798R-CY3

Anti-BNIP3L Rabbit Polyclonal Antibody (Cy3®)

Descripción: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Numero del catalogo: BOSSBS-5798R-CY3
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-9077R-CY5

Anti-CINP Rabbit Polyclonal Antibody (Cy5®)

Descripción: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Specifically, Cdk2 interacts with Cyclins A, B1, B3, D, or E to control cell cycle progression. The Cyclin-dependent kinase 2-interacting protein (CINP) interacts with components of the replication complex and Cdk2 and Cdc7, thereby providing a functional and physical link between Cdk2 and Cdc7 during firing of the origins of replication. However, CINP is phopshorylated by Cdc7, but not by Cdk2. CINP also interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress and G2 checkpoint integrity.
Numero del catalogo: BOSSBS-9077R-CY5
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-9077R-CY5.5

Anti-CINP Rabbit Polyclonal Antibody (Cy5.5®)

Descripción: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Specifically, Cdk2 interacts with Cyclins A, B1, B3, D, or E to control cell cycle progression. The Cyclin-dependent kinase 2-interacting protein (CINP) interacts with components of the replication complex and Cdk2 and Cdc7, thereby providing a functional and physical link between Cdk2 and Cdc7 during firing of the origins of replication. However, CINP is phopshorylated by Cdc7, but not by Cdk2. CINP also interacts with ATR-interacting protein and regulates ATR-dependent signaling, resistance to replication stress and G2 checkpoint integrity.
Numero del catalogo: BOSSBS-9077R-CY5.5
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-9672R-A350

Anti-C18ORF54 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Descripción: Encoding over 300 genes, chromosome 18 contains about 76 million bases. Trisomy 18, or Edwards syndrome, is the second most common trisomy after Downs syndrome. Symptoms of Edwards syndrome include low birth weight, a variety of physical development defects, heart deformations and breathing difficulty. Translocation between chromosome 18 and 14 is the most common translocation in cancers, and occurs in follicular lymphomas. Niemann-Pick disease, hereditary hemorrhagic telangiectasia and erythropoietic protoporphyria are associated with chromosome 18. The TGFβ modulators, Smad2, Smad4 and Smad7 are encoded by chromosome 18. The C18orf54 gene product has been provisionally designated C18orf54 pending further characterization.
Numero del catalogo: BOSSBS-9672R-A350
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-12142R-A488

Anti-InaD-Like Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Descripción: The membranes of myelinating Schwann cells are joined by tight, gap and adherens junctions, all of which are found in regions of noncompact myelin: the paranodal loops, incisures of Schmidt-Lanterman and mesaxons. Tight junctions help establish polarity in mammalian epithelia by forming a physical barrier that separates apical and basolateral membranes. Pals-associated tight junction protein (PATJ), the human homolog of Drosophila Discs Lost, is differentially localized in myelinating Schwann cells. PATJ associates with Claudin-1, CRB1 (a transmembrane protein that plays a role in epithelial cell polarity and photoreceptor development), and Pals1 (a Lin-7 associated protein). The PATJ/Pals1/CRB1 complex can form a tripartite tight junction in epithelial cells crucial to their integrity.
Numero del catalogo: BOSSBS-12142R-A488
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-12142R-A555

Anti-InaD-Like Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Descripción: The membranes of myelinating Schwann cells are joined by tight, gap and adherens junctions, all of which are found in regions of noncompact myelin: the paranodal loops, incisures of Schmidt-Lanterman and mesaxons. Tight junctions help establish polarity in mammalian epithelia by forming a physical barrier that separates apical and basolateral membranes. Pals-associated tight junction protein (PATJ), the human homolog of Drosophila Discs Lost, is differentially localized in myelinating Schwann cells. PATJ associates with Claudin-1, CRB1 (a transmembrane protein that plays a role in epithelial cell polarity and photoreceptor development), and Pals1 (a Lin-7 associated protein). The PATJ/Pals1/CRB1 complex can form a tripartite tight junction in epithelial cells crucial to their integrity.
Numero del catalogo: BOSSBS-12142R-A555
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-12515R-CY5

Anti-ASL Rabbit Polyclonal Antibody (Cy5®)

Descripción: ASL is a member of the lyase 1 family of proteins and is predominantly expressed in the liver. Localizing to the cytoplasm and existing as a homotetramer, ASL catalyzes the hydrolytic cleavage of argininosuccinic acid (ASA) to fumarate and arginine, an essential step of the urea cycle which is crucial for the detoxification of ammonia. This reaction is also involved in the biosynthesis of arginine. In addition, ASL shares high sequence homology with the avian and reptilian eye lens protein, d-crystallin. Mutations in the gene encoding ASL leads to an accumulation of ASA in body fluids and results in Arginosuc-cinic aciduria (ASAuria), an autosomal recessive disorder that is characterized by hyperammonemia, liver enlargement, convulsions, physical and mental retardation, episodic unconsciousness and dry and brittle hair showing trich-orrhexis nodosa (weak points or nodes in the hair shaft).
Numero del catalogo: BOSSBS-12515R-CY5
UOM: 1 * 100 µl
Proveedor: Bioss
Image Unavailable-BOSSBS-12515R-A555

Anti-ASL Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Descripción: ASL is a member of the lyase 1 family of proteins and is predominantly expressed in the liver. Localizing to the cytoplasm and existing as a homotetramer, ASL catalyzes the hydrolytic cleavage of argininosuccinic acid (ASA) to fumarate and arginine, an essential step of the urea cycle which is crucial for the detoxification of ammonia. This reaction is also involved in the biosynthesis of arginine. In addition, ASL shares high sequence homology with the avian and reptilian eye lens protein, d-crystallin. Mutations in the gene encoding ASL leads to an accumulation of ASA in body fluids and results in Arginosuc-cinic aciduria (ASAuria), an autosomal recessive disorder that is characterized by hyperammonemia, liver enlargement, convulsions, physical and mental retardation, episodic unconsciousness and dry and brittle hair showing trich-orrhexis nodosa (weak points or nodes in the hair shaft).
Numero del catalogo: BOSSBS-12515R-A555
UOM: 1 * 100 µl
Proveedor: Bioss
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