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Image Unavailable-BOSSBS-7416R-CY5

Anti-POLD2 Rabbit Polyclonal Antibody (Cy5®)

Numero del catalogo: (BOSSBS-7416R-CY5)
Proveedor: Bioss
Descripción: DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol α, β, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8).
UOM: 1 * 100 µl
Image Unavailable-1.07174.9026

Parafina, highly liquid Ph. Eur., BP, NF, JP, SAFC®

Proveedor: MERCK PRODUCTION CHEMICALS
Descripción: Residues of metal catalysts or metal reagents acc. to EMEA/C HMP/SWP/4446/2000 are not likely to be present.
Corresponds to Ph Eur,BP,NF,JP

FDS Certificados

Image Unavailable-BOSSBS-13018R-HRP

Anti-POLI Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numero del catalogo: (BOSSBS-13018R-HRP)
Proveedor: Bioss
Descripción: DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol Ω, which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13020R-HRP

Anti-POLK Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numero del catalogo: (BOSSBS-13020R-HRP)
Proveedor: Bioss
Descripción: DNA polymerase lambda (pol lambda), also designated DNA polymerase lambda or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol lambda is a member of the DNA polymerase type-X family. Pol lambda extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol ?may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol lambda and thus influences the ability of pol ?to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13019R-CY3

Anti-POLK Rabbit Polyclonal Antibody (Cy3®)

Numero del catalogo: (BOSSBS-13019R-CY3)
Proveedor: Bioss
Descripción: DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13020R-A488

Anti-POLK Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Numero del catalogo: (BOSSBS-13020R-A488)
Proveedor: Bioss
Descripción: DNA polymerase lambda (pol lambda), also designated DNA polymerase lambda or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol lambda is a member of the DNA polymerase type-X family. Pol lambda extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol ?may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol lambda and thus influences the ability of pol ?to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13020R-A350

Anti-POLK Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Numero del catalogo: (BOSSBS-13020R-A350)
Proveedor: Bioss
Descripción: DNA polymerase lambda (pol lambda), also designated DNA polymerase lambda or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol lambda is a member of the DNA polymerase type-X family. Pol lambda extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol ?may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol lambda and thus influences the ability of pol ?to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13019R-A680

Anti-DNA Polymerase Kappa/POLK Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Numero del catalogo: (BOSSBS-13019R-A680)
Proveedor: Bioss
Descripción: DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13020R

Anti-POLK Rabbit Polyclonal Antibody

Numero del catalogo: (BOSSBS-13020R)
Proveedor: Bioss
Descripción: DNA polymerase lambda (pol lambda), also designated DNA polymerase lambda or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol lambda is a member of the DNA polymerase type-X family. Pol lambda extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol ?may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol lambda and thus influences the ability of pol ?to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BWRLBS5699

Anti-DNA pol delta 3 Rabbit Polyclonal Antibody

Numero del catalogo: (BWRLBS5699)
Proveedor: Bioworld Technology
Descripción: Synthetic peptide, corresponding to the 421-466 of Human DNA pol delta 3.
UOM: 1 * 100 µG
Image Unavailable-BOSSBS-13019R-CY7

Anti-POLK Rabbit Polyclonal Antibody (Cy7®)

Numero del catalogo: (BOSSBS-13019R-CY7)
Proveedor: Bioss
Descripción: DNA polymerase lambda (pol Kappa), also designated DNA polymerase Kappa or Pol Beta2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol Kappa is a member of the DNA polymerase type-X family. Pol Kappa extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol Kappa may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol Kappa and thus influences the ability of pol Kappa to synthesize DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7416R-CY7

Anti-POLD2 Rabbit Polyclonal Antibody (Cy7®)

Numero del catalogo: (BOSSBS-7416R-CY7)
Proveedor: Bioss
Descripción: DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol α, β, ∂, and e are involved in DNA replication and repair (4). DNA pol ∂ and DNA pol e are multisubunit enzymes, with DNA pol ∂ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol © is the only DNA polymerase required for the replication of the mitochondrial DNA (6). DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis (7). DNA pol œ is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks (8).
UOM: 1 * 100 µl
Product Image-630-1019

Objectives for VWR® BI and TR 500 POL

Proveedor: VWR Collection
Descripción: Plan achromatic objective, brightfield and polarisation (20×), VWR®, Para: BI and TR 500 POL

Image Unavailable-BWRLBS1922

Anti-DNA pol alpha Rabbit Polyclonal Antibody [clone: K111]

Numero del catalogo: (BWRLBS1922)
Proveedor: Bioworld Technology
Descripción: Synthetic peptide, corresponding to amino acids 81-130 of Human DNA pol alpha.
UOM: 1 * 100 µG
Image Unavailable-BOSSBS-6972R-CY5.5

Anti-RNAP2 Rabbit Polyclonal Antibody (Cy5.5®)

Numero del catalogo: (BOSSBS-6972R-CY5.5)
Proveedor: Bioss
Descripción: RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The largest subunit of Pol II (referred to as RPB1 or RPB205) is a 1,840 amino acid protein that contains one C2H2-type zinc finger and a C-terminal domain comprised of several heptapeptide repeats. Although Pol II function requires the cooperation of all twelve subunits, the largest subunit conveys Pol II catalytic activity and, together with the second largest subunit, forms the active center of the Pol II enzyme. Additionally, the large subunit participates in forming the DNA-binding domain of Pol II, a groove that is necessary for transcription of the DNA template. Without proper function of the large subunit, mRNA synthesis and subsequent transcription elongation cannot occur.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6972R-A488

Anti-RNAP2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Numero del catalogo: (BOSSBS-6972R-A488)
Proveedor: Bioss
Descripción: RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The largest subunit of Pol II (referred to as RPB1 or RPB205) is a 1,840 amino acid protein that contains one C2H2-type zinc finger and a C-terminal domain comprised of several heptapeptide repeats. Although Pol II function requires the cooperation of all twelve subunits, the largest subunit conveys Pol II catalytic activity and, together with the second largest subunit, forms the active center of the Pol II enzyme. Additionally, the large subunit participates in forming the DNA-binding domain of Pol II, a groove that is necessary for transcription of the DNA template. Without proper function of the large subunit, mRNA synthesis and subsequent transcription elongation cannot occur.
UOM: 1 * 100 µl
Consulta de precio
El stock para este material es limitada pero puede estar disponible en un almacén cerca de usted. Por favor, asegúrese de que ha iniciado sesión en la web para que el stock disponible se puede mostrar. Si el call sigue apareciendo y usted necesita ayuda, por favor llámenos al 902 222 897 o por email en webshop.es@avantorsciences.com.
El stock para este material es limitada pero puede estar disponible en un almacén cerca de usted. Por favor, asegúrese de que ha iniciado sesión en la web para que el stock disponible se puede mostrar. Si el call sigue apareciendo y usted necesita ayuda, por favor llámenos al 902 222 897 o por email en webshop.es@avantorsciences.com.
Este producto se trata de un artículo regulado sometido a normativa que restringe su venta. Si procede, nos pondremos en contacto con usted para solicitarle la licencia o declaración de uso necesaria para poder proceder al suministro del producto.
Este producto se trata de un artículo regulado sometido a normativa que restringe su venta.
Si procede, nos pondremos en contacto con usted para solicitarle la licencia o declaración de uso necesaria para poder proceder al suministro del producto.
Este producto ha sido bloqueado por su organización. Por favor, pónganse en contacto con su departamento de compras para obtener más información.
El producto original ya no está disponible. Su sustituto se muestra a continuación.
El producto(s) marcados con este símbolo están descatalogados - se venden hasta acabar stock. Pueden encontrar alternativas buscando con el número de catálogo VWR listado arriba. Si necesita más ayuda, por favor llame al Servicio de atención al cliente de VWR al 902.222.897.
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