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Numero del catalogo: (90040.)

Proveedor: Biotium

Descripción: 5-(and-6)-Carboxy-2′,7′-dichlorofluorescein diacetate, succinimidyl ester is a useful fluorescent tracer that can passively diffuse into cells and covalently label intracellular proteins, resulting in long-term cell labeling. The reagent itself is colorless and nonfluorescent but becomes brightly green fluorescent once it is hydrolyzed by intracellular esterases.

UOM: 1 * 25 mg

Promoción

Proveedor: Spectrum Chemical

Descripción: Chlorophyllin Sodium Copper Salt | Non-graded Chlorophyllin Sodium Copper Salt supplied by Spectrum is indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use.

Numero del catalogo: (ICNA0215745105)

Proveedor: MP Biomedicals

Descripción: 2-Hydroxy-1-(2-hydroxy-4-sulfo-1-naphthylazo)-3-naphthoic acid is a useful indicator for calcium titrations with EDTA in the presence of magnesium.

UOM: 1 * 5 g

Certificados Promoción

Numero del catalogo: (90089.)

Proveedor: Biotium

Descripción: 5-ROX-PEO8 SE (full name: 5-Carboxy-X-rhodamine-PEO8-propionate, succinimidyl ester) has an approximately 32 Angstrom water-soluble PEG spacer that separates the red fluorescent ROX dye and the amine-reactive SE group.

UOM: 1 * 1 mg

Promoción

Numero del catalogo: (90004.)

Proveedor: Biotium

Descripción: 5(6)-ROX (full name: 5-(and-6)-Carboxy-X-rhodamine, triethylammonium salt (mixed isomers)) is a long wavelength rhodamine dye.

UOM: 1 * 25 mg

Promoción

Proveedor: Apollo Scientific

Descripción: alpha-(9-Fluorenylmethyloxycarbonyl)amino-omega-carboxy succinimidyl ester PEG

Numero del catalogo: (PRSI2253)

Proveedor: ProSci Inc.

Descripción: BACE Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (90006.)

Proveedor: Biotium

Descripción: 5-ROX (full name: 5-Carboxy-X-rhodamine, triethylammonium salt, single isomer) is a single isomer, long wavelength rhodamine dye.

UOM: 1 * 10 mg

Promoción

Proveedor: ENZO LIFE SCIENCES

Descripción: Water soluble and stable nitric oxide radical scavenger that shows in chemical and biological systems antagonistic action against the free nitric oxide radical (NO·). The inhibitory effects were almost 2-fold stronger than those of NMMA and NOARG. Reacts with nitric oxide in a stoichometric manner. Can be used for an improved detection of nitric oxide in activated macrophage cultures in combination with the Griess reagent. Protects against endotoxin shock.

Numero del catalogo: (PRSI38-153)

Proveedor: ProSci Inc.

Descripción: Insulin like growth factor binding protein 3 (IGF-BP3) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGF-BP) and at least four low affinity binding proteins referred to as IGF-BP related proteins (IGFBPrP). The IGF-BP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The cDNA sequence encoding the mature human IGF-BP3 is fused to the signal peptide of CD33. Human IGF-BP3 is the major IGF binding protein in plasma where it exists in a ternary complex with IGFI or IGFII and an acid labile subunit.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI6161)

Proveedor: ProSci Inc.

Descripción: PION Antibody: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patient's brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI5143)

Proveedor: ProSci Inc.

Descripción: APP Antibody: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patient's brains. Recently, Death Receptor 6 (DR6) was found to interact with an amino-terminal fragment of the Beta-amyloid protein (N-APP) in neurons, activating a caspase 6-dependent apoptotic event leading to axonal degeneration and pruning during development, suggesting that these two proteins are involved in neural development and may possibly play a role in Alzheimer's disease.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI5211)

Proveedor: ProSci Inc.

Descripción: UCMA Antibody: UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (ROCK600-401-J22)

Proveedor: Rockland Immunochemicals

Descripción: HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription. Anti-HDAC7 antibodies are ideal for researches interested in Breast Cancer, Cancer, Cell Cycle and Replication, Chromatin Research, Epigenetics, and Histone Deacetylases research.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI91-441)

Proveedor: ProSci Inc.

Descripción: Mannose-Binding Protein C (MBP-C) belongs to the Collectin family of innate immune defense proteins. MBL binds to an array of carbohydrate patterns on pathogen surfaces. Collectin family members share common structural features: a cysteine rich amino-terminal domain, a collagen-like region, an alpha-helical coiled-coil neck domain and a carboxy terminal C-type Lectin or carbohydrate recognition domain (CRD). MBL homotrimerizes to form a structural unit joined by N-terminal disulfide bridges. These homotrimers further associates into oligomeric structures of up to 6 units. Whereas two forms of MBL proteins exist in rodents and other animals. Human MBL-2 is 25 kDa. Human MBL-2 is a secreted glycoprotein that is synthesized as a 248 amino acid (aa) precursor that contains a 20 aa signal sequence, a 21 aa cysteine-rich region, a 58 aa collagen-like segment and a 111 aa C-type lectin domain that binds to neutral bacterial carbohydrates.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (8.41774.0025)

Proveedor: Merck

Descripción: Cloruro de (±)-(3-carboxi-2-hidroxipropil)trimetilamonio para síntesis, Sigma-Aldrich®

UOM: 1 * 25 g

FDS Promoción