Esta buscando: lad1

Numero del catalogo: (BOSSBS-1595R-CY3)

Proveedor: Bioss

Descripción: spindle microtubules. The checkpoint works by inhibiting the activity of the anaphase promoting complex, thereby preventing the degradation of several cell cycle regulators. Like other spindle checkpoint mutants, MAD1 loss-of-function mutants are sensitive to benomyl and cannot delay cell division in response to spindle depolymerization. Mad1p becomes hyperphosphorylated upon spindle depolymerization.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (BOSSBS-1302R-CY5)

Proveedor: Bioss

Descripción: Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L glutamate to g-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD has a restricted tissue distribution. It is highly expressed in the cytoplasm of GABAergic neurons in the central nervous system (CNS) and pancreatic beta cells. It is also present in other non-neuronal tissues such as testis, oviduct and ovary. GAD is also transiently expressed in non-GABAergic cells of the embryonic and adult nervous system, suggesting its involvement in development and plasticity. GAD exists as two isoforms, GAD65 and GAD67 (molecular masses of 65 and 67 kD, respectively) that are encoded by two different genes. GAD65 is an ampiphilic, membraneanchored protein, (585 amino acid residues) and is encoded on human chromosome 10. GAD67 is a cytoplasmic protein (594 amino acid residues) and is encoded on chromosome 2. There is 64% amino acid identity between the two isoforms, with the highest diversity located at the N terminus, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. The two isoforms appear to have distinct intraneuronal distribution in the brain. GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells. Islet-reactive T cells and primarily to GAD65 (also named beta cell autoantigen) can be detected in peripheral blood of 80% of recent-onset IDD patients and in pre-diabetic high-risk subjects before onset of clinical symptoms. This suggests that GAD may be an important marker in the early stages of the disease.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (BOSSBS-1302R-CY7)

Proveedor: Bioss

Descripción: Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L glutamate to g-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD has a restricted tissue distribution. It is highly expressed in the cytoplasm of GABAergic neurons in the central nervous system (CNS) and pancreatic beta cells. It is also present in other non-neuronal tissues such as testis, oviduct and ovary. GAD is also transiently expressed in non-GABAergic cells of the embryonic and adult nervous system, suggesting its involvement in development and plasticity. GAD exists as two isoforms, GAD65 and GAD67 (molecular masses of 65 and 67 kD, respectively) that are encoded by two different genes. GAD65 is an ampiphilic, membraneanchored protein, (585 amino acid residues) and is encoded on human chromosome 10. GAD67 is a cytoplasmic protein (594 amino acid residues) and is encoded on chromosome 2. There is 64% amino acid identity between the two isoforms, with the highest diversity located at the N terminus, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. The two isoforms appear to have distinct intraneuronal distribution in the brain. GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells. Islet-reactive T cells and primarily to GAD65 (also named beta cell autoantigen) can be detected in peripheral blood of 80% of recent-onset IDD patients and in pre-diabetic high-risk subjects before onset of clinical symptoms. This suggests that GAD may be an important marker in the early stages of the disease.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (BOSSBS-13263R)

Proveedor: Bioss

Descripción: Anti-GAD1/GAD2 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (ABCAAB184560-1ML)

Proveedor: Abcam

Descripción: Anti-MAD1L1/MAD1 Rabbit Monoclonal Antibody [clone: EPR14676-23]

UOM: 1 * 1 mL

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Numero del catalogo: (ABCAAB237999-100)

Proveedor: Abcam

Descripción: Anti-GAD67/GAD1 Mouse Monoclonal Antibody [clone: GAD1/2563]

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (USBI129020)

Proveedor: US Biological

Descripción: Anti-LAX1 Mouse Polyclonal Antibody

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (216-4354)

Proveedor: MULTIROIR

Descripción: Stackable polystyrene drawer unit ideal for organising and storing laboratory components, consumables, and various materials.

UOM: 1 * 1 UN

Promoción

Proveedor: Portwest

Descripción: This lab coat made from Kingsmill fabric (65% polyester and 35% cotton) is suitable for a wide range of work environments.

Proveedor: Sampling Systems

Descripción: These disposable ladles are ideal for the sterile and non sterile surface sampling of liquids. The robust HDPE construction is ideal for a huge number of liquid and water testing applications.

Numero del catalogo: (ANTIA77586-96)

Proveedor: ANTIBODIES.COM

Descripción: Monkey GAD1 ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of monkey GAD1 in serum, plasma, tissue homogenates, and other biological fluids.

UOM: 1 * 96 Tests

New Product Promoción

Proveedor: Portwest

Descripción: These stylish tunics are ideal for use in active work places, such as hospitals. The Kingsmill fabric made of 65% polyester and 35% cotton is cut to give a flattering fit and will retain its colour and shape after washing.

Proveedor: Abcam

Descripción: Anti-MAD1L1/MAD1 Rabbit Monoclonal Antibody [clone: EPR14676]

Numero del catalogo: (BOSSBS-1302R-CY3)

Proveedor: Bioss

Descripción: Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L glutamate to g-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD has a restricted tissue distribution. It is highly expressed in the cytoplasm of GABAergic neurons in the central nervous system (CNS) and pancreatic beta cells. It is also present in other non-neuronal tissues such as testis, oviduct and ovary. GAD is also transiently expressed in non-GABAergic cells of the embryonic and adult nervous system, suggesting its involvement in development and plasticity. GAD exists as two isoforms, GAD65 and GAD67 (molecular masses of 65 and 67 kD, respectively) that are encoded by two different genes. GAD65 is an ampiphilic, membraneanchored protein, (585 amino acid residues) and is encoded on human chromosome 10. GAD67 is a cytoplasmic protein (594 amino acid residues) and is encoded on chromosome 2. There is 64% amino acid identity between the two isoforms, with the highest diversity located at the N terminus, which in GAD65 is required for targeting the enzyme to GABA-containing secretory vesicles. The two isoforms appear to have distinct intraneuronal distribution in the brain. GAD65 has been identified as an autoantigen in insulindependent diabetes mellitus (IDDM) and stiff-man syndrome (SMS), IDDM is an autoimmune disease that results from T cell mediated destruction of pancreatic insulin-secreting beta cells. Islet-reactive T cells and primarily to GAD65 (also named beta cell autoantigen) can be detected in peripheral blood of 80% of recent-onset IDD patients and in pre-diabetic high-risk subjects before onset of clinical symptoms. This suggests that GAD may be an important marker in the early stages of the disease.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (USBI035867-BIOTIN)

Proveedor: US Biological

Descripción: Anti-GAD1 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

Promoción

Proveedor: Abcam

Descripción: Anti-KDM1/LSD1 Rabbit Monoclonal Antibody [clone: EPR6825]

New Product