Descripción: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMD9 is a non-ATPase subunit of the 19S regulator.

Numero del catalogo: BOSSBS-1372R-FITC

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: The gene encodes a 246-amino acid polypeptide containing an RNA binding motif, a putative nuclear localization signal, and phosphorylation sites. The alpha subunits comprises the outer rings of the proteasome. Some alpha subunits contain a functional nuclear localization signal; proteasomes are found in both the nuclear and cytoplasmic compartments of the cell. Alpha subunits may constitute a physical barrier that limits access of cytosolic proteins into the inner proteolytic chamber.

Numero del catalogo: BOSSBS-9355R-FITC

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2.

Numero del catalogo: BOSSBS-9352R-A488

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17.

Numero del catalogo: BOSSBS-9366R-A350

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: In eukaryotic cells, selective breakdown of cellular proteins is ensured by two distinct pathways, ubiquitination and degradation by the 26S proteasome. At specific stages of development, embryo- and tissue-specific components of the 26S proteasome are formed by developmentally regulated alternative splicing, including Rpn10a through Rpn10e (also designated pUb-R2 through pUb-R5). The pUb-R2 subunit, originally identified as S5a, is ubiquitously expressed and may perform proteolysis constitutively in a wide variety of cells. p44S10 is a highly conserved proteasome regulatory subunit that is expressed in heart, liver, skeletal muscle and pancreas. In addition to normal tissue expression, p44S10 is also expressed in several melanoma cell lines, such as MCF-7, 451Lu and WM164. Since forced expression of p44S10 in radial growth phase melanoma cells results in an increase in cellular proliferation, p44S10 may represent a potential link between regulation of proteasome activity and tumor cell proliferation in vivo.

Numero del catalogo: BOSSBS-9367R-A350

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase.

Numero del catalogo: BOSSBS-9365R-A750

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilising properties and the half-life of their target mRNAs.

Numero del catalogo: BOSSBS-6144R-A680

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Anti-PSMD2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Numero del catalogo: USBI040565-FITC

UOM: 1 * 200 µl

Proveedor: US Biological

Promoción

Descripción: Anti-PSMD9 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numero del catalogo: USBI040570-HRP

UOM: 1 * 200 µl

Proveedor: US Biological

Promoción

Descripción: Anti-ASIC4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numero del catalogo: USBI031530-HRP

UOM: 1 * 200 µl

Proveedor: US Biological

Promoción

Descripción: Anti-PLAC4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Numero del catalogo: USBI040125-HRP

UOM: 1 * 200 µl

Proveedor: US Biological

Promoción

Descripción: Anti-PLAC4 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))

Numero del catalogo: USBI040125-AP

UOM: 1 * 200 µl

Proveedor: US Biological

Promoción

Descripción: Anti-PSMD14 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Numero del catalogo: USBI040564-FITC

UOM: 1 * 200 µl

Proveedor: US Biological

Promoción

Descripción: Rabbit polyclonal to Proteasome 26S S2/PSMD2.

Numero del catalogo: ABCAAB125914-50

UOM: 1 * 50 µl

Proveedor: Abcam

Promoción

Descripción: Goat polyclonal to Proteasome 26S S2/PSMD2.

Numero del catalogo: ABCAAB26078-100

UOM: 1 * 100 µG

Proveedor: Abcam

Promoción

Descripción: Anti-PSMA5 Mouse Monoclonal Antibody [clone: 426CT8.5.1]

Numero del catalogo: ABGEAM2037B

UOM: 1 * 400 µl

Proveedor: Abgent

Promoción