Esta buscando: Chiral+Technologies

Proveedor: THERMO MATRIX TECHNOLOGIES

Descripción: PP or PS. These reservoirs offer an extra-wide base to add rigidity and stability, helping to avoid spills.

Promoción

Proveedor: THERMO MATRIX TECHNOLOGIES

Descripción: PP. Placas de 96 pocillos para almacenamiento de muestras.

Proveedor: STEMCELL Technologies

Descripción: Mouse monoclonal IgG1 antibody against human CD56 (NCAM), Alexa Fluor® 488-conjugated.

Proveedor: STEMCELL Technologies

Descripción: Immunomagnetic isolation of untouched human naïve CD8+ T cells

Numero del catalogo: (STMC100-0337)

Proveedor: STEMCELL Technologies

Descripción: Apoptosis staining and detection kit - 100 tests.

UOM: 1 * 100 UN

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Proveedor: STEMCELL Technologies

Descripción: Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor and a member of the tumor growth factor (TGF)-beta superfamily. The GDNF family of growth factors also includes neurturin, persephin, and artemin, which have seven conserved cysteine residues called cysteine-knot (Treanor <i>et al.</i>). GDNF family ligands signal through binding to specific GDNF-family receptor-α (GFRα) co-receptors and activate the RET receptor tyrosine kinase (Durbec <i>et al.</i>). Four different forms of GFRα co-receptors have been characterized (GFRα 1-4) out of which GDNF binds specifically to GFRα1 prior to forming a complex with RET (Airaksinen and Saarma). GDNF is known to promote survival and morphological differentiation of midbrain dopaminergic neurons in both in vivo and in vitro studies and increase their high-affinity dopamine uptake (Granholm <i>et al.</i>; Lin <i>et al.</i>). GDNF has also been shown to have restorative effects on dying dopaminergic neurons in response to degenerative toxins (Aoi <i>et al.</i>). GDNF, together with Human Recombinant BDNF (brain-derived neurotrophic factor; Catalog #78005), BrainPhys™ Neuronal Medium (Catalog #05790), and other supplements, can be used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Bardy <i>et al.</i>). This product is animal component-free.

New Product

Numero del catalogo: (STMC100-1421)

Proveedor: STEMCELL Technologies

Descripción: Stimulating T cells with SARS-CoV-2 (Spike Protein) Omicron BA.4/BA.5 Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This pool is provided as two lyophilised mixtures (subpools) from the spike glycoprotein of SARS-CoV-2 Omicron BA.4/BA.5 subvariant. The subpools contain 158 and 157 peptides, respectively, for a total of 315 peptides, and they consist of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 1270 on the spike protein. Through interactions with the angiotensin-converting enzyme 2 (ACE2) receptor, the spike protein enables the virus to attach to the cell membrane, and plays a critical role in viral entry (Hoffmann <i>et al.</i>; Walls <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

UOM: 1 * 1 UP

New Product Promoción

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Numero del catalogo: (STMC100-0180)

Proveedor: STEMCELL Technologies

Descripción: Fetal bovine serum for cell culture and research applications.

UOM: 1 * 500 mL

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Numero del catalogo: (STMC04230)

Proveedor: STEMCELL Technologies

Descripción: Methylcellulose-based medium without cytokines for human cells.

UOM: 1 * 80 mL

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Proveedor: STEMCELL Technologies

Descripción: Cell detachment solution.

Proveedor: STEMCELL Technologies

Descripción: Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-α, among them B cells, NK cells, mast cells, neutrophils, dendritic cells, microglia, endothelial cells, smooth muscle cells, cardiomyocytes, and fibroblasts. TNF-α has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immuno- suppressive responses. TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová and Hosek). Other effects of TNF-α include vasodilatation and edema formation.

Proveedor: STEMCELL Technologies

Descripción: Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf and Nicola). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit <i>et al.</i>), the activation of metalloproteases that cleave VCAM-1 (Levesque <i>et al.</i>), and the release of norepinephrine from the sympathetic nervous system (Katayama <i>et al.</i>), leading to the release or mobilization of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Mouse G-CSF was first purified from cultures of the WEHI-3B myelomonocytic leukemia cell line as the inducer of the terminal differentiation of WEHI-3B and other myeloid leukemia cell lines (Nicola <i>et al.</i>). It was later cloned in monkey COS cells from a cDNA library prepared with mRNA derived from mouse fibrosarcoma NFSA cells that produce G-CSF constitutively (Tsuchiya <i>et al.</i>). Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways.

Proveedor: CHIRAL TECHNOLOGIES

Descripción: Guard column coupler micro for 3 mm and 2 mm I-Ø

Proveedor: THERMO MATRIX TECHNOLOGIES

Descripción: The tubes are ideal for sample collection and storage, including DNA, blood, cell lines and tissue samples. A permanent 2D barcode is encapsulated onto the base of each tube to ensure long term sample identification and tracking.

Numero del catalogo: (MATRAB-1413)

Proveedor: THERMO MATRIX TECHNOLOGIES

Descripción: Abgene™ SmartCap mat, made from advanced thermoplastic elastomer (TPE), rapidly seals 96 samples at one time in a high-density storage format, affording maximum space saving benefits. Suitable for use with Thermo Scientific™ storage tubes ranging from 0,3 ml to 1,4 ml, the Abgene™ SmartCap Mat maintains a consistent seal down to –80 °C.

UOM: 1 * 1 UN

Promoción

Proveedor: STEMCELL Technologies

Descripción: Immunomagnetic isolation of untouched human leukocytes from whole blood.