Esta buscando: ProSci Inc.

Numero del catalogo: (PRSI16-952)

Proveedor: ProSci Inc.

Descripción: Anti-GADD45A Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

New Product Promoción

Numero del catalogo: (PRSI22-159)

Proveedor: ProSci Inc.

Descripción: Anti-CLIC1 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

New Product Promoción

Numero del catalogo: (PRSI60-063)

Proveedor: ProSci Inc.

Descripción: For WB starting dilution is: 1:1000.

UOM: 1 * 400 µl

New Product Promoción

Numero del catalogo: (PRSI18-251)

Proveedor: ProSci Inc.

Descripción: Anti-PRDX3 Rabbit Polyclonal Antibody

UOM: 1 * 50 µl

New Product Promoción

Numero del catalogo: (PRSI64-229)

Proveedor: ProSci Inc.

Descripción: Anti-ATG5 Rabbit Monoclonal Antibody [clone: 1358CT289.125.123]

UOM: 1 * 100 µl

New Product Promoción

Numero del catalogo: (PRSI57-234)

Proveedor: ProSci Inc.

Descripción: Anti-MBL2 Rabbit Polyclonal Antibody

UOM: 1 * 400 µl

Promoción

Numero del catalogo: (PRSI80-018)

Proveedor: ProSci Inc.

Descripción: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI79-996)

Proveedor: ProSci Inc.

Descripción: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI80-025)

Proveedor: ProSci Inc.

Descripción: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI2081)

Proveedor: ProSci Inc.

Descripción: ARC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI2075)

Proveedor: ProSci Inc.

Descripción: RICK Antibody: Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively. RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain. Overexpression of RICK induced apoptosis and activation of NF-kappa B and JNK. RICK interacts with members of the TRAF family, CLARP and caspase-1. Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1 beta. The messenger RNA of RICK is expressed in multiple human tissues.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI2059)

Proveedor: ProSci Inc.

Descripción: DNase II Antibody: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus. DNase II causes both chromatin condensation and DNA fragmentation. The genes encoding human, porcine, and murine DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (alpha) and 12 kDa (beta) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation. DNase II is ubiquitously expressed in human tissues.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI2099)

Proveedor: ProSci Inc.

Descripción: CX3CL1 Antibody: Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-alpha in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.

UOM: 1 * 100 µG

Promoción

Numero del catalogo: (PRSI25-413)

Proveedor: ProSci Inc.

Descripción: Nkx2-2 contains 1 homeobox DNA-binding domain which is essential for interaction with OLIG2. Nkx2-2 may be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI25-418)

Proveedor: ProSci Inc.

Descripción: SP4 belongs to the Sp1 C2H2-type zinc-finger protein family. It contains 3 C2H2-type zinc fingers. SP4 binds to GT and GC boxes promoters elements.It is a probable transcriptional activator.

UOM: 1 * 50 µG

Promoción

Numero del catalogo: (PRSI25-424)

Proveedor: ProSci Inc.

Descripción: TULP3 is a member of the tubby-like protein (TULP) family. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved C-terminal region of approximately 200 amino acid residues. The human and mouse TULP3 proteins share 69% amino acid sequence identity, with higher identity at the N and C termini than in the central region.This gene encodes a member of the tubby-like protein (TULP) family. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved C-terminal region of approximately 200 amino acid residues. The human and mouse TULP3 proteins share 69% amino acid sequence identity, with higher identity at the N and C termini than in the central region.

UOM: 1 * 50 µG

Promoción