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Product Image-JULA8900005

Software for Julabo units

Proveedor: JULABO GmbH
Descripción: Una amplia gama de aplicaciones que permite la programación, visualización y registro de procesos dependientes de la temperatura y del tiempo en combinación con instrumentos de laboratorio. Comunicación perfecta y posibilidades de conexión en red a través de la interfaz RS232/RS485, USB (con conversor opcional) y asistente de Profibus con la automatización del laboratorio.

Product Image-BEHRB00233702

Kjeldhal steam distillation units

Proveedor: BEHR
Descripción: behr steam distillation units are not just high performance units and reliable partners in your daily laboratory routine. An essential factor in the development and design of the devices was also the safety of the user.

Product Image-BRND709432

Height Adapter for Liquid Handling Station

Proveedor: Brand
Descripción: Height Adapter for Liquid Handling Station

Image Unavailable-PRSI92-522

Mouse recombinant IL36 beta (from E. coli)

Numero del catalogo: (PRSI92-522)
Proveedor: ProSci Inc.
Descripción: Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signalling pathways in target cells linked to a pro-inflammatory response. IL-36B is synthesised in several cells including resting and activated monocytes, and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 signalling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases , inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activating p38 MAPK phosphorylation in BMDCs.Moreover, interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and inducing the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4+ T cells and splenocytes.
UOM: 1 * 50 µG
Product Image-AGLSM5320AA

ZAG DNA Analyser System

Numero del catalogo: (AGLSM5320AA)
Proveedor: AGILENT
Descripción: Parallel capillary electrophoresis system for automated high-throughput DNA fragment analysis.
UOM: 1 * 1 UN
Product Image-17-3712-03

Immobilised metal ion affinity chromatography (IMAC) media, Ni Sepharose™ excel

Proveedor: Cytiva
Descripción: Ni Sepharose™ excel is an IMAC medium pre-charged with nickel ions very strongly bound to a chelating ligand. Samples that usually cause stripping of metal ions can, therefore, be loaded to the medium. Ni Sepharose™ excel is designed primarily for capture and purification of histidine-tagged proteins secreted into cell culture supernatants from eukaryotic cells such as insect cells or CHO cells.

Product Image-STMC78014.1

Mouse Recombinant G-CSF

Proveedor: STEMCELL Technologies
Descripción: Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf and Nicola). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit <i>et al.</i>), the activation of metalloproteases that cleave VCAM-1 (Levesque <i>et al.</i>), and the release of norepinephrine from the sympathetic nervous system (Katayama <i>et al.</i>), leading to the release or mobilization of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Mouse G-CSF was first purified from cultures of the WEHI-3B myelomonocytic leukemia cell line as the inducer of the terminal differentiation of WEHI-3B and other myeloid leukemia cell lines (Nicola <i>et al.</i>). It was later cloned in monkey COS cells from a cDNA library prepared with mRNA derived from mouse fibrosarcoma NFSA cells that produce G-CSF constitutively (Tsuchiya <i>et al.</i>). Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways.

Product Image-STMC78026

Mouse Recombinant IL-11

Proveedor: STEMCELL Technologies
Descripción: Interleukin 11 (IL-11) is a pleiotropic cytokine with effects on various tissues including the bone marrow, brain, and intestinal mucosa (Du and amp; Williams). It belongs to the IL-6 family of cytokines that share a common signal transducer, gp130. Culture of mouse bone marrow cells with IL-11 in combination with IL-3, IL-6, and stem cell factor induces significant expansion and proliferation of colony-forming cells in vitro (Peters <i>et al.</i>). In addition, in combination with IL-3, IL-11 significantly enhances the growth of megakaryocytic colonies in vitro, suggesting its role in augmenting mouse megakaryopoiesis (Yonemura <i>et al.</i>). IL-11 is expressed in a wide range of normal adult mouse tissues, including the central nervous system, thymus, lung, and bone. The mouse IL-11 cDNA was cloned using an expression library generated from the lipopolysaccharide-induced mouse fetal thymic cell line, T2 (Morris <i>et al.</i>). The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases. IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs. Recently, IL-11 has gained interest for its role in the pathogenesis of diseases in dysregulated mucosal homeostasis associated with STAT3 upregulation, including gastrointestinal cancers (Putoczki <i>et al.</i>).

Image Unavailable-ICNA117002200

Nucleic acid purification system, MPure-12™, MP Biomedicals

Numero del catalogo: (ICNA117002200)
Proveedor: MP Biomedicals
Descripción: MPure-12™ is a bench top automated system for rapid purification of nucleic acids from a wide variety of bio-specimens using magnetic bead separation technology. It has a uniquely designed magnetic bead processing chamber and is fully integrated with easy to use pre-packaged reagent kits.
UOM: 1 * 1 UN
Product Image-736-0760

Robotic tips for Eppendorf epMotion® automated pipetting system

Proveedor: Thermo Fisher Scientific
Descripción: These automation tips for the epMotion automated pipetting system are available in non sterile, sterile, and sterile filtered versions.

Environmentally Preferable

Product Image-AXYGFT-384-BK-R

Robotic tips for FLIPR Tetra, Axygen®

Proveedor: Corning
Descripción: These tips are manufactured to stringent specifications under strict process controls and assembled via automation to ensure consistent performance and quality. Designed for use in Molecular devices FLIPR tetra automation systems.

Certificados Environmentally Preferable

Product Image-BRND709465

Holders for Liquid Ends

Proveedor: Brand
Descripción: Holders for Liquid Ends

Product Image-STMC78064.2

Mouse Recombinant SCF (E. coli-expressed)

Proveedor: STEMCELL Technologies
Descripción: Stem cell factor (SCF) is an early-acting cytokine that plays a pivotal role in the regulation of embryonic and adult hematopoiesis. SCF promotes cell survival, proliferation, differentiation, adhesion, and functional activation of cells at multiple levels of the hematopoietic hierarchy. Together with other cytokines such as thrombopoietin and Flt3/Flk-2 Ligand, SCF is commonly used to promote expansion of primitive hematopoietic stem cells and multi-potent progenitor cells in culture (Huang <i>et al.</i>; Kent <i>et al.</i>). In synergy with various growth factors, including IL-2, IL-3, IL-6, IL-7, G-CSF, and erythropoietin, SCF increases proliferation and differentiation of myeloid and erythroid progenitor cells and a subset of lymphoid progenitor cells (Broudy). In the mouse, SCF is essential during fetal gonadal development (Mauduit). It is produced by stromal cells in the fetal liver, bone marrow, and thymus, in the central nervous system, in keratinocytes, and in the gut mucosa, and can function as a chemotactic and chemokinetic factor. SCF exists in two biologically active splice forms: a soluble and a transmembrane isoform. Upon binding to its receptor (c-kit tyrosine kinase receptor; CD117), it activates PI3K, JAK/STAT, and MAPK pathways. SCF and signaling from c-kit has also been reported to play an important role in pigmentation, fertility, vasculogenesis, motility of the gut via c-kit-positive interstitial cells of Cajal, and in the migration of neuronal stem and progenitor cells to sites of injury in the brain (Lennartsson and Ronnstrand).

Product Image-VELPS303A0380

Automatic solvent extractors, SER 158 series

Proveedor: VELP SCIENTIFIC
Descripción: A fully automated and cloud enabled solvent extractor capable of a high sample throughput, offering state-of-the-art technology for a fast, precise and accurate extractions in complete safety according to Randall or Twisselmann techniques.

Product Image-29-0220-94

Protein purification systems, ÄKTA™ start

Numero del catalogo: (29-0220-94)
Proveedor: Cytiva
Descripción: ÄKTA start is an easy to use chromatography system that automates manual purification procedures using, for example, HiTrap columns. It offers an entry level chromatography solution for the preparative purification of proteins at lab scale.
UOM: 1 * 1 UN

Certificados


Product Image-736-2043

Microplacas de 384 pocillos, Falcon®

Proveedor: Corning
Descripción: Falcon® 384 microplates are compatible with automation systems and meet standard ANSI/SBS footprint dimensions for microplates.

Certificados

Consulta de precio
El stock para este material es limitada pero puede estar disponible en un almacén cerca de usted. Por favor, asegúrese de que ha iniciado sesión en la web para que el stock disponible se puede mostrar. Si el call sigue apareciendo y usted necesita ayuda, por favor llámenos al 902 222 897 o por email en webshop.es@avantorsciences.com.
El stock para este material es limitada pero puede estar disponible en un almacén cerca de usted. Por favor, asegúrese de que ha iniciado sesión en la web para que el stock disponible se puede mostrar. Si el call sigue apareciendo y usted necesita ayuda, por favor llámenos al 902 222 897 o por email en webshop.es@avantorsciences.com.
Este producto se trata de un artículo regulado sometido a normativa que restringe su venta. Si procede, nos pondremos en contacto con usted para solicitarle la licencia o declaración de uso necesaria para poder proceder al suministro del producto.
Este producto se trata de un artículo regulado sometido a normativa que restringe su venta.
Si procede, nos pondremos en contacto con usted para solicitarle la licencia o declaración de uso necesaria para poder proceder al suministro del producto.
Este producto ha sido bloqueado por su organización. Por favor, pónganse en contacto con su departamento de compras para obtener más información.
El producto original ya no está disponible. Su sustituto se muestra a continuación.
El producto(s) marcados con este símbolo están descatalogados - se venden hasta acabar stock. Pueden encontrar alternativas buscando con el número de catálogo VWR listado arriba. Si necesita más ayuda, por favor llame al Servicio de atención al cliente de VWR al 902.222.897.
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