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Numero del catalogo: (BOSSBS-8682R-CY5)

Proveedor: Bioss

Descripción: The activation of RaP1 by cAMP is independent of PKA and is mediated by recently discovered family of guanine nucleotide exchange factors (GEFs) called cAMP-GEFs or Epacs. The Epac signaling therefore represents a novel mechanism for cAMP signaling with in the cAMP cascade. There are 2 members of the Epac family, Epac1 and Epac 2. Both proteins are multidomain proteins containing an autoinhibitory cAMP-binding domain that inhibits the catalytic region and a DEP domain (dishevelled, Egl-10 and pleckstrin homology domain) targeting the membrane anchors. EPAC2 has an additional cAMP-binding site in its N-terminus that binds cAMP with low affinity. EPAC1 mRNA is broadly expressed, with particularly high levels occurring in the thyroid, ovary, kidney and certain brain regions, whereas expression of EPAC2 mRNA appears to be restricted to the brain and adrenal glands. Epac 1 and Epac 2 also interact with light chain 2 (LC2) or MAP1A that serves as a scaffolding structure to stabilize the signal transduction complex. The Epac 1-selective were generated against unique antigenic sequences form near N-terminus and between RasGEFN and Ras GEF domains. The to Epac 1are affinity purified over immobilized antigen based chromatography.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (BOSSBS-8682R-A647)

Proveedor: Bioss

Descripción: The activation of RaP1 by cAMP is independent of PKA and is mediated by recently discovered family of guanine nucleotide exchange factors (GEFs) called cAMP-GEFs or Epacs. The Epac signaling therefore represents a novel mechanism for cAMP signaling with in the cAMP cascade. There are 2 members of the Epac family, Epac1 and Epac 2. Both proteins are multidomain proteins containing an autoinhibitory cAMP-binding domain that inhibits the catalytic region and a DEP domain (dishevelled, Egl-10 and pleckstrin homology domain) targeting the membrane anchors. EPAC2 has an additional cAMP-binding site in its N-terminus that binds cAMP with low affinity. EPAC1 mRNA is broadly expressed, with particularly high levels occurring in the thyroid, ovary, kidney and certain brain regions, whereas expression of EPAC2 mRNA appears to be restricted to the brain and adrenal glands. Epac 1 and Epac 2 also interact with light chain 2 (LC2) or MAP1A that serves as a scaffolding structure to stabilize the signal transduction complex. The Epac 1-selective were generated against unique antigenic sequences form near N-terminus and between RasGEFN and Ras GEF domains. The to Epac 1are affinity purified over immobilized antigen based chromatography.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (BOSSBS-8682R)

Proveedor: Bioss

Descripción: The activation of RaP1 by cAMP is independent of PKA and is mediated by recently discovered family of guanine nucleotide exchange factors (GEFs) called cAMP-GEFs or Epacs. The Epac signaling therefore represents a novel mechanism for cAMP signaling with in the cAMP cascade. There are 2 members of the Epac family, Epac1 and Epac 2. Both proteins are multidomain proteins containing an autoinhibitory cAMP-binding domain that inhibits the catalytic region and a DEP domain (dishevelled, Egl-10 and pleckstrin homology domain) targeting the membrane anchors. EPAC2 has an additional cAMP-binding site in its N-terminus that binds cAMP with low affinity. EPAC1 mRNA is broadly expressed, with particularly high levels occurring in the thyroid, ovary, kidney and certain brain regions, whereas expression of EPAC2 mRNA appears to be restricted to the brain and adrenal glands. Epac 1 and Epac 2 also interact with light chain 2 (LC2) or MAP1A that serves as a scaffolding structure to stabilize the signal transduction complex. The Epac 1-selective were generated against unique antigenic sequences form near N-terminus and between RasGEFN and Ras GEF domains. The to Epac 1are affinity purified over immobilized antigen based chromatography.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (ABCAAB213181-100)

Proveedor: Abcam

Descripción: Anti-DEPDC5 Rabbit Monoclonal Antibody [clone: EPR20497-23]

UOM: 1 * 100 µl

Promoción

Proveedor: TCI

Descripción: Dietilo ftalato ≥99.0% (por GC)

Proveedor: Thermo Fisher Scientific

Descripción: Dietilo ftalato 99%

FDS

Proveedor: Thermo Fisher Scientific

Descripción: DEPC (Pirocarbonato de dietilo) 97%, puro

FDS

Numero del catalogo: (23995.467)

Proveedor: VWR Chemicals

Descripción: Dietilo ftalato ≥98%, TECHNICAL

UOM: 1 * 25 L

FDS Certificados Promoción

Numero del catalogo: (23395.362)

Proveedor: VWR Chemicals

Descripción: Dietilo ftalato ≥99.5%, GPR RECTAPUR®

UOM: 1 * 5 L

FDS Certificados Promoción

Proveedor: Abcam

Descripción: Anti-DEPDC5 Rabbit Monoclonal Antibody [clone: EPR20497-23]

Proveedor: VWR Chemicals

Descripción: DEPC is used to inactivate RNase enzymes from water and other laboratory utensils. DEPC covalently modifies histidine residues in RNase enzymes. DEPC can be used with PBS or MOPS buffer, but is incompatible with Tris and HEPES.

FDS Certificados

Numero del catalogo: (MEMMUF1060PLUSD4)

Proveedor: MEMMERT

Descripción: [EN]LOCK DOOR PROCESS-DEP (ONLY TWINDISP 1 * 1 UN

UOM: 1 * 1 UN

Promoción

Numero del catalogo: (ORIGRG205770)

Proveedor: OriGene

Descripción: ORF CLONE HUMAN NM_22783 1 * 10 µG

UOM: 1 * 10 µG

Promoción

Numero del catalogo: (MARO50000210.02)

Proveedor: MARTOR ARGENTAX

Descripción: Cuchillo de seguridad resistente con retracción automática para todo tipo de tareas de corte normales. 1 * 1 UN

UOM: 1 * 1 UN

Promoción

Numero del catalogo: (MARO50000610.02)

Proveedor: MARTOR ARGENTAX

Descripción: Cuchillo de seguridad resistente con retracción automática para todo tipo de tareas de corte normales. 1 * 1 UN

UOM: 1 * 1 UN

Promoción

Numero del catalogo: (MARI1000300)

Proveedor: MARIENFELD

Descripción: MICROSLIDE 76X26X1MM CUT COMPL. FROSTED 1 * 1.000 UN

UOM: 1 * 1.000 UN

Promoción