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Descripción: DNA polymerase activity is essential for replication, repair, recombination and mutagenesis. DNA polymerases can often bypass DNA lesions that block DNA replication, thereby allowing the replication of damaged DNA. One such DNA polymerase is the distributive enzyme DNA Pol i, which is encoded by the POLI gene. POLI is located on human chromosome 18q21.2, a region often implicated in the etiology of many human cancers. At thymine templates, DNA Pol i is highly error-prone when replicating undamaged DNA in that it favors the misincorporation of guanine over the correct nucleotide, adenosine. DNA Pol i also promotes the replication of damaged DNA by misincorporating deoxynucleotides opposite DNA lesions. DNA Pol i acts sequentially with DNA Pol , which is essential for damage-induced mutagenesis, to complete the DNA lesion bypass. Therefore, replication involving DNA Pol i is likely to be highly mutagenic.

Numero del catalogo: BOSSBS-13018R-A680

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Anti-DNA Polymerase iota Mouse Monoclonal Antibody [clone: OTI1H9]

Numero del catalogo: ANTIA321857-100

UOM: 1 * 100 µl

Proveedor: ANTIBODIES.COM

New Product Promoción

Descripción: Accessory for microscopes, Set for white LED modules for IOTA

Numero del catalogo: VISIMTA411

UOM: 1 * 1 UN

Proveedor: VISION ENGINEERING

Promoción

Descripción: Anti-PKC zeta+PKC iota Rabbit Monoclonal Antibody [clone: EP1491Y]

Numero del catalogo: ABCAAB247446-100

UOM: 1 * 100 µG

Proveedor: Abcam

Promoción

Descripción: Anti-PRKCI Mouse Monoclonal Antibody [clone: 1G11]

Numero del catalogo: USBI131805

UOM: 1 * 100 µG

Proveedor: US Biological

Promoción

Descripción: Anti-PRKCI Rabbit Polyclonal Antibody (APC (Allophycocyanin))

Numero del catalogo: USBIP9103-70L-APC

UOM: 1 * 200 µl

Proveedor: US Biological

Promoción

Descripción: KAPPA-CARRAGEENAN 1 * 5 g

Numero del catalogo: H60117.06

UOM: 1 * 5 g

Proveedor: Thermo Fisher Scientific

FDS Certificados Promoción

Descripción: KAPPA-CARRAGEENAN 1 * 25 g

Numero del catalogo: H60117.14

UOM: 1 * 25 g

Proveedor: Thermo Fisher Scientific

FDS Certificados Promoción

Descripción: PKC IOTA PROTEIN (ACTIVE) 1 * 10 µG

Numero del catalogo: ABCAAB60850-10

UOM: 1 * 10 µG

Proveedor: Abcam

Promoción

Descripción: Rabbit monoclonal [HL1279] to PKC alpha (phospho T410) + PKC delta (phospho T410) + PKC epsilon (phospho T410) + PKC beta 1 + PKC gamma (phospho T410) + PKC zeta (phospho T410) - BSA and Azide free.

Numero del catalogo: ABCAAB313842-100UL

UOM: 1 * 100 µl

Proveedor: Abcam

Promoción

Descripción: [EN]RECOMBINANT HUMAN PKC IOTA PROTEIN 1 * 5 µG

Numero del catalogo: ABCAAB60850-5

UOM: 1 * 5 µG

Proveedor: Abcam

Promoción

Descripción: RABBIT POLYCLONAL TO DNA POLYMERASE IOTA 1 * 100 µl

Numero del catalogo: ABCAAB272883-100

UOM: 1 * 100 µl

Proveedor: Abcam

Promoción

Descripción: HUMAN PRKCI PKC IOTA KNOCKOUT HELA CEL 1 * 1 KIT

Numero del catalogo: ABCAAB258604-1

UOM: 1 * 1 KIT

Proveedor: Abcam

Promoción

Descripción: VpreB is expressed in pre-B lymphocytes, but not in mature B cells or in other blood cell lineages. The gene which encodes VpreB maps to human chromosome 22q11.2. The VpreB and Lambda 5 genes encode the Iota and Omega polypeptide chains, respectively, which associate with the Ig-Mu chain to form a molecular complex that is expressed on the surface of pre-B cells. This complex presumably regulates Ig gene rearrangements in the early steps of B cell differentiation. In the mouse the two genes are simultaneously expressed in pre-B cells and belong to the same transcription unit. A primary transcript is synthesized from which the pre-B and Lambda 5 mRNAs are derived by alternative splicing. In the human, however, the two genes are separate and do not belong to the same transcription unit.

Numero del catalogo: BOSSBS-12326R

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. There have been at least 12 different PKC isoforms identified in humans to date including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. PKC gamma is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).

Numero del catalogo: BOSSBS-3730R-A488

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción

Descripción: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. There have been at least 12 different PKC isoforms identified in humans to date including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. PKC gamma is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).

Numero del catalogo: BOSSBS-3626R-A488

UOM: 1 * 100 µl

Proveedor: Bioss

Promoción