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Numero del catalogo: (BOSSBS-12095R-A350)

Proveedor: Bioss

Descripción: Glutamate receptors mediate most excitatory neurotransmissions in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are divided into two categories, namely NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors consist of seven structurally related subunits, designated GluR-1 to -7, and are primarily responsible for fast excitatory neurotransmissions carried out by glutamate. GluR-delta 1 (Glutamate receptor delta-1 subunit), also known as GRID1, is a multi-pass membrane protein that belongs to the kainate/AMPA receptor family and is expressed primarily in the brain. Localized to the cell junction and the postsynaptic cell membrane, GluR-delta 1 functions as a glutamate receptor that regulates synaptic transmissions in the central nervous system (CNS) and is thought to play an important role in synaptic plasticity. Defects in the gene encoding GluR-delta 1 are associated with schizophrenia, a chronic and severe brain disorder.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (HEATHS23453)

Proveedor: HEATHROW

Descripción: Construidas en polipropileno de alto impacto, estas resistentes cubetas de almacenamiento con tapa y separadores están diseñadas para ayudar a organizar un laboratorio.

UOM: 1 * 5 UN

Promoción

Numero del catalogo: (BOSSBS-1803R-CY5)

Proveedor: Bioss

Descripción: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].

UOM: 1 * 100 µl

Promoción

Proveedor: DELTALAB

Descripción: Las criocajas, de cartón, blancas, con compartimentos premontados, están diseñadas para el almacenamiento y la conservación de muestras congeladas.

Numero del catalogo: (BOSSBS-3008R-A555)

Proveedor: Bioss

Descripción: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (BOSSBS-3008R-HRP)

Proveedor: Bioss

Descripción: The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (PRSI3467)

Proveedor: ProSci Inc.

Descripción: Caspase-7 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression.

UOM: 1 * 100 µG

Promoción

Proveedor: Simport Scientific

Descripción: PC, autoclavable.

Numero del catalogo: (PRTWB909BKR)

Proveedor: Portwest

Descripción: Aesthetic styling and functional design make this travel trolley bag a must have item. Internally the bag is split into three sections with hook and loop strip dividers, making it ideal for separating your items.

UOM: 1 * 1 UN

Promoción

Proveedor: HEATHROW

Descripción: Las cajas de congelación True North® (cajas criogénicas) se han diseñado pensando en la sostenibilidad y están fabricadas con un polipropileno ondulado o de película fina especialmente formulado.

Proveedor: Rubbermaid Commercial Products

Descripción: The Rubbermaid Commercial executive quick cart is the durable mobile cart solution for housekeeping, janitorial and maintenance environments.

Proveedor: Corning

Descripción: Cajas de policarbonato reutilizables.

Certificados

Proveedor: DWK Life Sciences

Descripción: Estas cajas criogénicas están fabricadas con tableros de aglomerado de alta calidad y recubiertas con polietileno.

Proveedor: HEATHROW

Descripción: Cajas criogénicas, de cartón, para el almacenamiento de pequeñas muestras y tubos.

Proveedor: HEATHROW

Descripción: De cartón, blanco.

Proveedor: EPPENDORF

Descripción: Las cajas de almacenamiento proporcionan un almacenamiento seguro para sus tubos de muestra en un diseño que ahorra espacio. La amplia cartera ofrece una selección para tubos de 0,5 a 50 ml.