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Proveedor: Thermo Scientific

Descripción: Las centrífugas de sobremesa Thermo Scientific™ Megafuge ST1/ST1R Plus ofrecen controles intuitivos y versatilidad para potencia en cada giro.

Proveedor: Bohlender

Descripción: Protection sheets made from PTFE or FEP.

Proveedor: Hettich

Descripción: High performance, compact centrifuges developed for high sample throughput as well as for high sample volumes.

Numero del catalogo: (512-0714)

Proveedor: THARMAC GmbH

Descripción: The genius among the centrifuges. Automatic rotor detection and speed adjustment on max. 2000 rpm when using cytorotors.

UOM: 1 * 1 UN

Promoción

Numero del catalogo: (115-3173)

Proveedor: DESCO

Descripción: ESD workstation cover protects the workstation from ESD, dust and other contaminants.

UOM: 1 * 1 UN

Promoción

Numero del catalogo: (SHANA78710013)

Proveedor: Epredia

Descripción: EZ funnel starter kit, includes 25 EZ Megafunnels™, 20 EZ single white Cytofunnels®, 20 EZ double cytofunnels and Cytoslides®, Centrífuga de sobremesa

UOM: 1 * 1 UN

Promoción

Proveedor: LENZ, E. (Lenz Laborglas GmbH & CO.KG)

Descripción: DURAN®, borosilicate glass, clear.

Proveedor: TRESTON

Descripción: These worktables are a suitable solution for industrial laboratories and research and development centers. They are designed to accommodate the necessary measurement equipment and other tools ergonomically at a safe distance for use. These laboratory benches fit also to education purposes. Modularity and accessories are individually adjustable according the task and human requirements.

Proveedor: Hettich

Descripción: The ROTOFIX 46 centrifuges are designed for use in research and industrial laboratories.

Numero del catalogo: (PRSI90-269)

Proveedor: ProSci Inc.

Descripción: CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal centre formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumour cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

UOM: 1 * 50 µG

Promoción

Proveedor: witeg Labortechnik

Descripción: Borosilicate glass 3.3, plastic coated.

Proveedor: Hettich

Descripción: Centrífugas de excelente rendimiento y completa gama de accesorios que les permiten realizar prácticamente cualquier tarea de centrifugado.

Proveedor: Thermo Fisher Scientific

Descripción: Made from 3,2 mm thick closed-cell polyethylene foam this bench liner provides cushioning and liquid barrier protection.

Numero del catalogo: (BOSSBS-2734R-A680)

Proveedor: Bioss

Descripción: Transcriptional repressor mainly required for germinal centre (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (BOSSBS-2734R-A750)

Proveedor: Bioss

Descripción: Transcriptional repressor mainly required for germinal centre (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.

UOM: 1 * 100 µl

Promoción

Numero del catalogo: (BOSSBS-0087R-CY5)

Proveedor: Bioss

Descripción: The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.

UOM: 1 * 100 µl

Promoción