Esta buscando: 2-Fluoropyrimidine

Numero del catalogo: (BTIUBNUM0716-50)

Proveedor: Biotium

Descripción: This antibody recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UOM: 1 * 50 µl

Promoción

Numero del catalogo: (EDQMY0000765)

Proveedor: EDQM

Descripción: Organic Standard, Fluorouracil impurity F, 2-ethoxy-5-fluoropyrimidin-4(1H)-one (2-ethoxy-5-fluorouracil), Ph. Eur. standard

UOM: 1 * 10 mg

Promoción

Numero del catalogo: (343922-1)

Proveedor: Merck Millipore (Calbiochem‎)

Descripción: 5-fluorouracilo, Millipore®

UOM: 1 * 1 g

Promoción

Proveedor: Thermo Scientific

Descripción: 5-Fluorouridina ≥97%

FDS Certificados

Proveedor: Cayman Chemical

Descripción: 5-Fluorocitosina

Numero del catalogo: (PROOICRS0310)

Proveedor: LGC Standards PROMOCHEM

Descripción: 5-Fluorocitosina

UOM: 1 * 100 mg

Promoción

Proveedor: Cayman Chemical

Descripción: 5-fluorouracilo

Numero del catalogo: (PROOICRS0312)

Proveedor: LGC Standards PROMOCHEM

Descripción: 5-fluorouracilo

UOM: 1 * 100 mg

Promoción

Proveedor: Thermo Scientific

Descripción: 5'-Deoxy-5-fluorocytidine 95%

New Product

Proveedor: MP Biomedicals

Descripción: 5-Fluorouracil (5-FU) inhibits the activity of thymidylate synthetase, which affects pyrimidine synthesis and leads to depletion of intracellular TTP pools.

Numero del catalogo: (PRSI33-918)

Proveedor: ProSci Inc.

Descripción: Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UOM: 1 * 100 µG

New Product Promoción

Numero del catalogo: (PRSI34-176)

Proveedor: ProSci Inc.

Descripción: It recognises a protein of 36 kDa, identified as Thymidylate Synthase (TS). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UOM: 1 * 100 µG

New Product Promoción

Proveedor: Thermo Fisher Scientific

Descripción: Thermo Scientific 5-Fluoroorotic Acid (5-fluorouracil-6-carboxylic acid monohydrate; 5-FOA) is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate (OMP) dicarboxylase

Numero del catalogo: (PRSI33-219)

Proveedor: ProSci Inc.

Descripción: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UOM: 1 * 100 µG

New Product Promoción

Proveedor: MP Biomedicals

Descripción: FOA is a derivative of a pyrimidine precursor and is selectively toxic to yeast cells which synthesize orotidine-5’-phosphate decarboxylase. FOA has been used in a positive selection for uracil-requiring mutants(in the presence of large numbers of wild-type cells) lacking OMPdecase or OPRTase activities. This results in efficient strains for effective transformation systems.

Numero del catalogo: (PRSI33-744)

Proveedor: ProSci Inc.

Descripción: Recognises a 485 amino acid protein (55 kDa monomer/110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), also called Thymidine Phosphorylase (TP, Tymp) or Gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.

UOM: 1 * 100 µG

New Product Promoción