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Anti-SLC22A17 Rabbit Polyclonal Antibody (Cy7®)

Numero del catalogo: (BOSSBS-0444R-CY7)

Proveedor: Bioss

Descripción: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

UOM: 1 * 100 µl

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Anti-SLC22A17 Rabbit Polyclonal Antibody (Cy5®)

Numero del catalogo: (BOSSBS-0444R-CY5)

Proveedor: Bioss

UOM: 1 * 100 µl

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Anti-FTH1 Rabbit Polyclonal Antibody (Cy7®)

Numero del catalogo: (BOSSBS-5907R-CY7)

Proveedor: Bioss

Descripción: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).

UOM: 1 * 100 µl

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Ferroína (1,10-Fenantrolina-hierro(II) sulfato) 1/40 mol/l, AVS TITRINORM indicador redox

Proveedor: VWR Chemicals

Descripción: Ferroína (1,10-Fenantrolina-hierro(II) sulfato) 1/40 mol/l, AVS TITRINORM indicador redox

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Anti-Aconitase 1 Ser711 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Numero del catalogo: (BOSSBS-12958R-A680)

Proveedor: Bioss

Descripción: Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IREBP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.

UOM: 1 * 100 µl

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Hierro (III) fluoruro, anhidro 99%

Proveedor: Apollo Scientific

Descripción: Hierro (III) fluoruro, anhidro 99%

Hierro (II) bromuro, anhidro

Numero del catalogo: (APOSIN2050-100G)

Proveedor: Apollo Scientific

Descripción: Hierro (II) bromuro, anhidro

UOM: 1 * 100 g

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Human Recombinant NGAL (from Cells)

Numero del catalogo: (PRSI91-967)

Proveedor: ProSci Inc.

Descripción: LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. LCN2 binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. LCN2 is involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. LCN2 is involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

UOM: 1 * 0,05 mg

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