Esta buscando: STEMCELL Technologies

Proveedor: STEMCELL Technologies

Descripción: Thrombopoietin (TPO) is a key regulator of megakaryocytopoiesis and thrombopoiesis <i>in vitro</i> and <i>in vivo</i>. TPO stimulates the proliferation and maturation of megakaryocytes and has an important role in regulating the level of circulating platelets in vivo (Bartley <i>et al.</i>; de Sauvage <i>et al.</i>; Foster <i>et al.</i>; Sohma <i>et al.</i>). TPO also promotes the survival, self-renewal, and expansion of hematopoietic stem cells and primitive multilineage progenitor cells. It is commonly used with other cytokines such as stem cell factor (SCF) and Flt3/Flk-2 ligand to promote expansion of primitive hematopoietic cells in culture (Hitchcock and Kaushansky). The TPO receptor, c-Mpl, is expressed at all stages of megakaryopoiesis, from hematopoietic stem and progenitor cells to mature platelets (Ng <i>et al.</i>).

Proveedor: STEMCELL Technologies

Descripción: Immunomagnetic positive selection of human CD3+ cells (e.g. T cells).

Proveedor: STEMCELL Technologies

Descripción: CD40 ligand is a type II transmembrane glycoprotein that belongs to the tumor necrosis factor (TNF) superfamily (Quezada <i>et al.</i>). CD40 ligand forms a bioactive homotrimer that exists as both soluble and membrane-bound forms (Khandekar <i>et al.</i>). CD40 ligand is expressed on T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. Its receptor, CD40, is expressed on B cells, dendritic cells, macrophages, monocytes, platelets, endothelial cells, and epithelial cells (van Kooten and Banchereau). Binding of CD40 ligand to CD40 stimulates B cell proliferation, immunoglobulin class switching, antibody secretion, and T cell-dependent humoral responses. Dysregulation of CD40 ligand contributes to immune deficiency in HIV and AIDS (Rickert <i>et al.</i>). CD40 ligand has also been linked to the pathology of atherosclerosis, atherothrombosis, and restenosis (Hassan <i>et al.</i>).

Proveedor: STEMCELL Technologies

Descripción: Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma <i>et al.</i>). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau <i>et al.</i>). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).

Proveedor: STEMCELL Technologies

Descripción: Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi and Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto and Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi and Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick <i>et al.</i>). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto and Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata <i>et al.</i>).

Proveedor: STEMCELL Technologies

Descripción: Vascular endothelial growth factor (VEGF-165) is a heparin-binding homodimeric glycoprotein involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 (R1) and VEGFR-2 (R2), and activates Raf/MEK/ERK and PI3K/AKT pathways (Ferrara <i>et al.</i>). It plays an important role in neurogenesis both in vitro and <i>in vivo</i> (Storkebaum <i>et al.</i>). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara <i>et al.</i>). VEGF-165 contains two polypeptide chains of 165 amino acids each. This product is animal component-free.

Proveedor: STEMCELL Technologies

Descripción: Transforming growth factor (TGF) beta 2 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. Similar to TGF-β1 and -β3, TGF-β2 signals via serine-threonine kinase type I and II receptors and activates signal transduction via SMAD family proteins, regulating a variety of functions such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism (de Caestecker; Massague; Zuniga <i>et al.</i>). TGF-β2 is important in many developmental processes; for example, mice with TGF-β2 deletions show defects in the development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems (Dunker and Kreiglstein).

Numero del catalogo: (STMC79016)

Proveedor: STEMCELL Technologies

Descripción: For removing nucleases from DNA/RNA samples and terminating enzymatic reactions.

UOM: 1 * 4 mL

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Proveedor: STEMCELL Technologies

Descripción: Immunomagnetic positive selection of human cells with your own mouse IgG1 antibody.

Proveedor: STEMCELL Technologies

Descripción: Immunomagnetic enrichment of untouched human hematopoietic progenitor cells.

Numero del catalogo: (STMC17864)

Proveedor: STEMCELL Technologies

Descripción: Immunomagnetic positive selection of human memory B cells.

UOM: 1 * 1 KIT

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Numero del catalogo: (STMC100-0507)

Proveedor: STEMCELL Technologies

Descripción: FRET-based peptide substrate for detection of protease activity of coronaviruses - 100 tests.

UOM: 1 * 100 Tests

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Proveedor: STEMCELL Technologies

Descripción: Rabbit monoclonal IgG antibody against SARS-CoV, SARS-CoV-2 (2019-nCoV) nucleoprotein (HEK293-expressed recombinant).

Numero del catalogo: (STMC100-0583)

Proveedor: STEMCELL Technologies

Descripción: Human monoclonal IgG1 antibody against SARS-CoV-2 (2019-nCoV) S protein (HEK293-expressed recombinant).

UOM: 1 * 100 µG

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Numero del catalogo: (STMC100-0334)

Proveedor: STEMCELL Technologies

Descripción: Assay buffer for labeling with Annexin V - 50 ml.

UOM: 1 * 50 mL

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Proveedor: STEMCELL Technologies

Descripción: Persephin is a neurotrophic factor that belongs to the glial cell line-derived neurotrophic factor (GDNF) family. Persephin shares a large degree of structural similarity to GDNF, artemin, and neurturin, and has overall neuroprotective activity. Persephin signals through GRFα4 (glycosylphosphatidylinositol (GPI)-linked GDNF receptor family member) which signals through the receptor tyrosine kinase RET. Unlike GDNF and neurturin, persephin only promotes the growth and survival of central dopaminergic and motor neurons, but not peripheral neurons (Milbrandt <i>et al.</i>). In vitro persephin only promotes survival of neurons that co-express GPI-linked GRFα4 and RET (Enokido <i>et al.</i>; Lindahl <i>et al.</i>). Mice lacking persephin showed increased cell death after cerebral ischemia, however administration of persephin before ischemia dramatically reduced neuronal cell death (Tomac <i>et al.</i>). This product is animal component-free.