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4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline ≥97% (by 1H-NMR)

Numero del catalogo: (ENZOALX270448M005)

Proveedor: ENZO LIFE SCIENCES

Descripción: Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=51nM). Displays ~15-fold greater selectivity over p38α MAPK (IC50=740nM). Inhibits TGF-β-dependent cellular growth (IC50=89nM in NIH 3T3 mouse fibroblasts) and transcription activation (IC50=47nM in mink lung cells). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.

UOM: 1 * 5 mg

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